Student Profiles Archive - CARE Scholars
Here you will find information about past and present students funded through scholarships administered by the Undergraduate Research Center - Sciences. We are proud of the achievements of our research scholars.
Please click on the program year to get information about the supported students, their mentors and their research projects.
| Ms. Indara Suarez
Ms. Indara Suarez
Mentor: Dr. Bernard Nefkens
Title: Energy calibration of the crystal ball detector with MAMI-C
Ms. Suarez began pursuing her Ph.D. in Physics at Texas A&M University in 2009.
| Ms. Lauren Sanchez
Ms. Lauren Sanchez
Mentor: Dr. Luisa Iruela-Arispe
Title: Generation and Characterization of a Progesterone Receptor Reporter Mouse Model
Lauren Sanchez is a senior Molecular, Cell, and Developmental Biology major under the guidance of Dr. Luisa Iruela-Arispe. Her primary research focus is on the relationship of the female hormone progesterone and vascular homeostasis. Progesterone is used by women of all ages in both contraceptives and hormone replacement therapy. Studies by the Women’s Health Initiative have demonstrated users of hormonal therapy are at a greater risk for developing heart disease. Preliminary studies have suggested a link between expression of the progesterone receptor (PR) and vascular permeability, which may contribute to the development of heart disease. The widespread usage of progesterone warrants further study on effects of progesterone on the mammalian vasculature. To contribute to this study, Lauren has generated a reporter mouse model, in which the reporter gene lacZ has been substituted for the PR gene. Using the PRlacZ mouse model, she will characterize wild-type patterns of PR expression in mice of varying developmental stages. The model will be compared against other PR mouse models in which the PR is misexpressed, including PR conditional excision models, in which PR is deleted in specific tissues by Cre-mediated recombination. Preliminary analysis of one particular model, the VENPR, in which PR is deleted from the vascular endothelium, suggests important role of progesterone in suppression of the inflammatory response, especially at sites of vascular injury. Lauren will continue this study by challenging knockout mice with bacterial lipopolysaccaride (LPS) and subsequent analysis by immunohistochemistry. Lauren hopes to continue her studies in an MD/PhD program this fall.
| Mr. Sergio Pacheco
Mr. Sergio Pacheco Jr.
Mentor: Dr. Ken Bradley
Title: Determining the role of cAMP-responsive element binding (CREB) protein in anthrax edema toxin-induced ANTXR expression
Bacillus anthracis secretes two toxins that contribute to the overall pathogenesis associated with the disease anthrax. Both toxins share a receptor binding subunit, protective antigen (PA), which binds to one of two identified anthrax toxin receptors (ANTXRS) and mediates entry of the catalytic subunits into the host-cell cytosol. Edema factor, the catalytic subunit of edema toxin (ET), is an adenylate cyclase that impairs host defenses by raising cellular cAMP levels. Recently, the Bradley lab demonstrated that ET induces an increase in ANTXR expression. This increase is dependent on ET’s ability to increase cAMP levels and is mediated through a protein kinase A (PLA)-directed signaling. Activation of PKA leads to activation of seeral transcription factors including the cAMP response element binding (CREB) protein. CREB binding sites are present upstream on ANTXR1 and ANTXR2 genes suggesting that upregulation of these genes might be CREB dependent. To test this I will generate RAW264.7 cells expressing one of three CREB genes: a wild type CREB or one of three dominant negative CREB mutants. I will determine whether the ET-induced increase in ANTXR expression is CREB dependent by measuring relative ANTXR mRNA levels using reverse transcription quantitative PCR (RT-qPCR) and measuring the ability of cells to bind a fluorescently labeled-PA using flow cytometry. This study will expand our current understanding of anthrax intoxication and could lead to development of toxin activity inhibitors.
| Ms. Isabel Neacato
Ms. Isabel Neacato
Mentor: Dr. Manuel Penichet
Title: The analysis of an anti-TfR IgG3-avidin fusion protein alone and in combination with other potential drugs for cancer immunotherapy
Isabel Neacato is a first year UC LEADS student and is majoring in biochemistry. She began working for the laboratory of Dr. Manuel L. Penichet last year. She works under the direct supervision of a post-doctoral fellow, Dr. Tracy R. Daniels, who together with Dr. Penichet is mentoring her. The Penichet’s laboratory is focused on the development of novel immunotherapeutics for the treatment of cancer.
Previous research has shown that the human transferrin receptor (hTfR) is responsible for the delivery of iron into cells through its binding to transferrin. The high TfR expression on the surface of cancer cells, up to 100-fold higher than the average of normal cells, its extracellular accessibility, and its ability to get internalized, make this receptor a promising tool for targeted immunotherapy of cancer. Utilizing this information, the Penichet’s laboratory developed a mouse/human chimeric antibody fusion protein composed of avidin genetically fused to a human IgG3 that specifically targets the ectodomain of the hTfR. Their initial goal was to use this molecule (anti-TfR IgG3-Av) as a universal vector to deliver biotinylated agents into cancer cells. However, they discovered that anti-hTfR IgG3-Av alone possesses a strong intrinsic anti-proliferative/pro-apoptotic activity against hematopoietic malignant cell lines. Importantly, this activity can be potentially enhanced by its conjugation to biotinylated therapeutic agents such as the plant toxin, saporin. Isabels’ early work focused on determining the specificity of this protein by its delivery of biotinylated saporin and the apoptotic pathway induced by such treatment. Her current work focuses on testing anti-TfR IgG3-Av in combination with other potential drugs in multiple myeloma model cell systems (IM-9 and U266 cell lines) to determine whether the therapeutic effect of the fusion protein can be enhanced. The effective drug concentration is determined by a dose-response, afterwhich it is tested in combination with anti-TfR IgG3-Av in order to determine whether a more potent growth inhibition can be achieved.
Ms. Neacato began pursuing a joint M.D./Ph.D. degree in Microbiology at the University of Illinois Urbana-Champaign in 2011.
| Mr. Jason Lin
Mr. Jason Lin
Mentor: Dr. Sarah Tolbert
Major: Physical Chemistry
Title: Encapsulation of fluorescent polymers by cowpea chlorotic mottle virus
For the past three years in laboratory of Professor Sarah H. Tolbert at the Department of Chemistry and Biochemistry, I have been working on encapsulating the semiconducting polymer (MPS-PPV) using Cowpea Chlorotic Mottle Virus (CCMV). The experiments I have conducted with my graduate mentor, Benny Ng, have confirmed that we can use the polymers and viral capsid proteins to form spherical or tubular structures by controlling the physical conformation of the polymers in buffer. We are currently investigating how its fluorescence properties are related to the physical conformation of MPS-PPV inside of the capsids. My latest research project is to measure friction coefficient of cubic mesoporous titania using atomic force microscope.
Working in the Tolbert's lab has widened my exposure of different research interests and enabled me to realize why I enjoy research. In the classroom, students are often taught specific techniques and equations to obtain a solution. However, in research I am free to use my own imagination to find a variety of paths to the solution. Research is also different from many careers which reuse established knowledge to perform the same task routinely. Researchers, however, use established knowledge to make new discoveries in science and technology. Personally, I would rather be the one solving the puzzle than the one repeating the solution.
As of Fall 2012, Mr. Lin is completing a Ph.D. in Chemistry & Biochemistry at UC Santa Barbara.
| Ms. Carolyn Kingsley
Ms. Carolyn Kingsley
Mentor: Dr. Joan Valentine
Title: Substitution of superoxide dismutase mimics for authentic SOD is highly specific
The Cu,Zn-Superoxide sidmutase (SOD1) enzyme catalyzes the dismutation of superoxide ions to hydrogen peroxide and oxygen in the mitochondrial intermembrane space, peroxisomes, cytosol, and nuclei of eukaryotic cells. Yeasts lacking this enzyme (sod1Δ) exhibit a variety of phenotypes including slow growth in air and aerobic lysine and methionine auxotrophies. Low molecular weight, non-peptidyl, superoxide dismutase (SOD) mimics have been reported to show SOD activity in vitro and to be effective in treating conditions related to oxidative stress in animals. Surprisingly, many were shown preciously to be inactive or toxic in our yeast system. With hopes of reversing the described phenotypes of (sod1Δ) yeast, we surveyed newly available manganese porphyrins MnTM-2-PyP, MnTE-2-PyP, MnTMPyP and MnTBAP. These compounds were used for in vivo aerobic growth studies with wild type yeast strain eg103 and (sod1Δ) yeast strain eg118. Of the four SOD mimics, MnTM-2-PyP was the only compound to show significant growth rescue of eg118 including close to normal growth in air and restoration of growth in medium lacking lysine or methionine. The ability to rescue yeast lacking SOD1 is a very stringent test for mimic activity. These results indicate that the ability of a small molecule to substitute for authentic SOD is very specific. It may depend on the precise structure of the compound and/or its ability to get to the precise subcellular location.
Ms. Kingsley began pursuing a Ph.D. in Medicinal Chemistry & Pharmacology at UC Irvine in 2009.
| Mr. Mikael Guzman-Karlsson
Mr. Mikael Guzman- Karlsson
Mentor: Dr. Alcino Silva
Major: Physiological Science
Title: The Involvement of the Retrosplenial Cortex in Spatial Memories
Mikael Guzman Karlsson recently graduated from UCLA in 2007 with a dual degree in Neuroscience and Physiological Science as well as a minor in Scandinavian Studies. As an undergraduate student, Mikael worked in Dr. Alcino Silva’s lab studying the consolidation of memories and more specifically the cortical brain regions involved in the storage and retrieval of spatial memories.
Memory consolidation is defined as the process by which perceptual, motor, and cognitive information is encoded from a primarily vulnerable memory trace into enduring long-term memory. The mechanisms required for initial memory processing in the hippocampus have been extensively studied, specifically emphasizing the role of the hippocampus as crucial to the formation and storage or recent memories. However, much less is known regarding the machinery underlining permanent memory storage in cortical areas. Recent studies have begun to uncover the secrets of remote memory organization as well as pinpoint the network of cortical regions that support remote memory and the molecular events crucial for their consolidation. Through the use of a variety of techniques such as behavioral studies, neuroanatomic lesions, pharmacological activations, and immunohistochemistry, Mikael has been attempting to determine whether or not the retrosplenial cortex possesses a memory-related function when it comes to the storage and retrieval of spatial memories.
Mikael is continuing his research in Dr. Silva’s lab by working full-time as a paid staff research assistant. Within the next year, Mikael plans to apply to MD-PhD programs where he hopes to fuse his desire for neuroscience and medicine. He would like to thank Dr. Silva and everyone in the Silva Lab as well as Dr. Tama Hasson and everyone at the URC/CARE office for all the economic and intellectual support that allowed him to perform the research that he so greatly enjoys.
Mr. Guzman-Karlsson began pursuing a joint M.D./Ph.D. in Neurobiology at the University of Alabama at Birmingham in 2009.
| Mr. Rilwan Balogun
Mr. Rilwan Balogun
Mentor: Dr. Debi Nayak and Dr. Subrata Barman
Title: Importance of amino acids E339, D340, and Q405 of Nucleoprotein in Influenza A virus life cycle.
Influenza virus infection and release of progeny viruses both occur specifically at the apical plasma membrane in polarized epithelial cells. It was shown that the Nucleoprotein (NP) transported to the apical plasma membrane independent of other viral proteins during viral assembly. We have shown that NP interacts with actin microfilaments, and it is speculated that this interaction allows it to be transported to the apical plasma membrane. It was further shown in vitro that amino acids 338-340, 342, and 405 of NP are responsible for this interaction. Therefore, we are exploring the role of these amino acids in virus life cycle. These critical amino acids of NP (WSN and PR8) were mutated to alanine (F338A, E339A/D340A, R342A, and Q405A) in Pol I-II plasmid by site-directed mutagenesis. WSN and PR8 NP Mutants F338A, R342A exhibited growth and plaque morphology similar to WT virus during viral rescue. This showed that the respective amino acids were not essential in virus life cycle. Viral rescue for WSN NP E339A/D340A and Q405A, and PR8 NP Q405A were unsuccessful. Transfection and immunoprecipitation of WSN E339A/D340A and Q405A mutant NP showed that the mutant nucleoproteins were made but, likely, they did not form the vRNP complex. Plasmid containing PR8 NPE339A/D340A is under construction. Cellular localization of all the mutant proteins will be examined by confocal Immunofluorescence. To examine the cellular localization of E339A/D340A and Q405A mutant NP proteins among other viral proteins (i.e. wt virus infected and mutant NP transfected cells), Flag-tag strategy will be used.
Mr. Balogun began pursuing a joint M.S./Ph.D. at UC San Francisco in Fall of 2010.
| Ms. Ruth Alvarez
Ms. Ruth Alvarez
Mentor: Dr. Wenyuan Shi
Title: Construction of the Che X T. denticola Mutant
Ms. Alvarez earned an M.S. at UCLA in Oral Biology in 2010 and began pursuing a joint Ph.D/D.D.S degree the following year, also at UCLA.
| Mr. Jose Zamolloa
Mr. Jose Zamalloa
Mentor: Dr. Cesar Fernandez
Title: Understanding the function of the SUMO protease, Ulp1p, in RNA metabolism
Jose Zamalloa is a Biochemistry who will be graduating by the Spring of 2009. He began working in the Chanfreau Laboratory since Summer of 2008. He works under the direct supervision of post-doctoral fellow, Dr. Cesar Fernandez. The Chanfreau Laboratory is interested in the study of gene expression regulation in eukaryotic cells with emphasis on post-transcriptional steps
Post-translational modification of proteins can activate, deactivate, or modify the function of a protein. An example of post-translational modification is the Ubiquitin system, whose most notable role is to target proteins to the Proteasome for degradation by covalent attachment of Ubiquitin. After the discovery of Ubiquitin, similar proteins have been found that contain the same conserved three-dimensional folding. This project aims to study the effects of the yeast SUMO ( small ubiquitin-like modifier) system on the metabolism of various non-coding RNAs. In this project Jose will analyze the levels of different RNAs by depletion studies of Ulp1p, an essential protease that removes Smt3p, the yeast SUMO protein, from covalently attached proteins. A bioinformatics search and biochemical results from the lab suggest that Ulp1p may have a role in the assembly of small nucleolar RNPs (snoRNPs). By using the regulatory TET-promoter transcription of ULP1 will be blocked. To confirm Ulp1p depletion, cell extracts will be analyzed for the presence of hemagglutinin (HA) tagged Ulp1p by western blot. At different control points of depletion cell extracts will be collected and analyzed to look at the levels of various noncoding RNAs, including snoRNAs, snRNAs, and tRNAs, by northern blots. These RNA levels will be compared before and after depletion of Ulp1p and the results will determine if the biogenesis or stability of the RNAs are affected by depletion of Ulp1p. By examining the results obtained on Ulp1p Jose will begin to elucidate its possible role in non-coding RNA metabolism and have a better understanding of its function on cellular regulation.
| Ms. Ninel Vartanian
Ms. Ninel Vartanian
Mentor: Dr. Gil Travish
Title: Testing of Optical Sub-Wavelength Resonant Periodic Structure Micro-Accelerators
Ninel Vartanian is a third year undergraduate student majoring in Physics. She has participated in PEERS and SPUR and has been working in the Particle Beam Physics Laboratory (PBPL) since summer of 2008. Under the supervision of Dr. Gil Travish, she is involved with the Micro-Accelerator Platform Project.
The Micro-Accelerator Platform, a laser-driven accelerating device measuring less than a millimeter in each dimension, has a variety of applications in industry and medicine. The structure consists of two parallel slabs, with each possessing reflective surfaces and with one having periodic slots which allows transversely incident laser light to enter the gap between the two planes. The resonance in the electric field created in the gap can be measured indirectly through the spectral response of the device. Using a combination of an interferometer and a fiber coupled spectrometer, the prototype structures are aligned and measured. With the aid of a three-axis nanometer accuracy positioning device, the bottom slab (essentially a mirror) is aligned with the top slotted structure. The interferometer and a low power laser are used to position the slabs. A 800nm Titanium-Sapphire oscillator with a bandwidth of greater than 100nm is used for the spectral measurements. The spectra of both transmitted and reflected beams are measured for a number of structures. The spectral data does not match the previously prepared simulations, and resonance has yet to be observed. As an improvement to the structure, the bottom slab will be changed from a brag-stack mirror to a one layer metal structure for clearer measurements. Nevertheless, this work represents the first time that measurements have been done on an optical micro-accelerator. Further future plans include use of a white light source in combination with a high resolution monochromator.
| Ms. Allison Truong
Ms. Allison Truong
Mentor: Dr. Lee Goodglick
Major: Physiological Science
Title: Expression of antimicrobial human neutrophil defensin peptides of innate immunity in lavage colon rinses of active inflammatory bowel disease
Allison Truong is a second year student majoring in Biology and minoring in Public Health. She began conducting research in the laboratory of Dr. Lee Goodglick in December 2007 and works under the supervision of graduate student Michelle Li.
The Goodglick laboratory is investigating inflammatory bowel disease (IBD), which is a family of debilitating chronic inflammatory diseases of the intestinal tract. The two major subvariants of this disease are ulcerative colitis (UC) and Crohn's disease (CD). UC is a chronic inflammation of the inner lining (mucosa) of the large intestine (colon) while CD can potentially affect all regions of the gastrointestinal tract. Individuals with either disease have an increased risk of colon cancer. Interestingly, both conditions represent a spectrum of diseases with variable severity, progression course, and responsiveness to therapy. Therefore, the goal is to find novel biomarkers which stratify individuals with IBD based on disease progression and severity, clinical outcome, and/or responsiveness to therapy using powerful global proteomics approaches (MALDI-TOF Mass Spectrometry) to identify associated protein profiles in the intestine of individuals with IBD with verification of MS findings via Immublot Assays and various other statistical analyses. In association with physicians at Cedars-Sinai Medical Center, highly unique type of patient sample, colonic rinses, were collected. These rinses monitor the eukaryotic and prokaryotic milieu directly at the interface of the colonic surface; the prediction being that such colonic environmental changes are responsive to, and in some cases casually responsible for disease progression. One family of proteins of note, which we have identified, is alpha defensins. Interestingly, the levels of alpha defensins 1, 2, and 3 may stratify healthy, UC, and CD individuals.
| Mr. Francisco Sandoval
Mr. Francisco Sandoval
Mentor: Dr. Rhonda Voskuhl
Major: Physiological Science
Title: Synergistic anti-inflammatory and neuroprotective effects of Interferon Beta and Estrogen Receptor β Ligand treatment in Experimental Autoimmune Encephalomyelitis
Francisco Sandoval is a third year student majoring in Physiological Science. He began conducting research in the laboratory of Dr. Rhonda Voskhul in fall 2007 and works under the direct supervision of graduate student Sienmi Du. The Voskuhl laboratory uses the mouse model Experimental Autoimmune Encephalomyelitis (EAE) to study Multiple Sclerosis (MS), a chronic inflammatory autoimmune disease that affects the central nervous system.
MS results in demyelination of white matter, leading to neurodegeneration in the CNS. Interferon beta (IFNβ) is a widely approved therapy for MS and EAE. Other labs have shown that treatment with IFNβ in EAE leads to indirect neuroprotection through anti-inflammatory activity. Our lab has recently shown that diarylpropionitrile (DPN), an estrogen receptor-beta ligand, is directly neuroprotective, with no evidence of anti-inflammatory effects in EAE. It is therefore likely that IFNβ and DPN work through separate mechanisms to reduce EAE. Possible synergism between IFNβ and DPN were tested in ameliorating EAE. The spinal cord of EAE mice was evaluated late in disease for changes in axonal density and macrophage infiltration. EAE mice treated with the combination of IFNβ and DPN exhibited a lesser degree of clinical disease and reflected significantly higher axonal densities and less infiltrating cells compared to vehicle treated animals. Our work provides evidence that there is a synergistic effect between IFNβ and DPN without antagonistic side effects in EAE progression. Our findings demonstrate that these drugs combined suppress EAE severity providing greater neuroprotection than IFNβ alone, suggesting a valuable alternative in therapeutic strategy for MS patients.
| Ms. Irma Ortiz
Ms. Irma Ortiz
Mentor: Dr. Volker Hartenstein
Major: Molecular, Cell and Developmental Biology
Title: Analysis of Neuronal Morphology in the Absence of Glia
Irma Ortiz is a third year undergraduate student majoring in MCDB. Dr. Volker Hartenstein and graduate student, Shana Spindler are mentoring her. She is conducting research on glial cells and their possible effect on neuron branching morphology. Glial cells have been implicated in neuroblast proliferation and axonal pathfinding. Two apoptosis-inducing genes, hid and reaper, were expressed in Drosophila glial cells under the temperature sensitive UAS/Gal4 promoter Nirvana 2 (Nrv 2). UAS Green Fluorescence protein (UASGFP), also driven in glial cells by the Nrv 2 promoter, allowed a visualization of glia via GFP fluorescence. An antibody against Repo, a glia specific protein, was used to visualize glia when GFP was not expressed at non-permissive temperatures. At 18 oC, GFP and the pro-apoptotic genes were not expressed and glial cells were present. At 29 oC, however, the pro-apoptotic genes were active and Repo staining confirmed that glial cells were absent. By Comparing Drosophila brains with and without glia, there were differences in the axon branching points. The next approach would be to conduct more experiments to confirm the results. A second approach would be to do temperature shifting in pupa and late third instar larva to follow axon branching throughout development in brains with and without glia.
| Ms. Raylene Moreno
Ms. Raylene Moreno
Mentor: Dr. Jennifer Jay
Major: Civil and Environmental Engineering
Title: Bacterial Inactivation in Beach Sediments of Santa Monica Bay
Raylene has been working with Dr. Jay in the Department of Civil and Environmental Engineering since her Freshman year at UCLA. She has worked closely with Ph.D. candidate, Kathryn Mika, researching the persistence of fecal indicator bacteria and pathogens in beach sediments. Through field testing and bench-scale microcosms, Raylene investigates how biological and physical factors (solar radiation, mechanical mixing, temperature, and moisture) influence die-off rates of E.coli, Enterococci, and Salmonella in beach sediments following coastal sewage spills.
Ms. Moreno hopes to continue working with Dr. Jay for the duration of her undergraduate career. She will pursue research in the field of engineering throughout her graduate studies. She is very grateful to the CARE staff, Dr. Jay, and her graduate students, for making this experience possible.
| Ms. Lanny Gov
Ms. Lanny Gov
Mentor: Dr. Benhur Lee
Major: Microbiology, Immunology and Molecular Genetics
Title: Effects of Galectin-1 Treated Dendritic Cells on T-cell Polarization
Lanny is a fourth year Microbiology, Immunology, and Molecular Genetics student with a minor in Classical Civilization. She has been conducting research under the mentorship of Dr. Benhur Lee since January 2008. Her current project focuses on dendritic cells (DCs), professional antigen-presenting cells that play a role in both the innate and adaptive arms of the immune system.
Dr. Lee’s lab has previously shown that galectin-1, a galactosidase-binding lectin, acts as a novel endogenous activator of immature DCs. Galectin-1 is known to positively and negatively affect cell function based on the activation state of the cell. Since DCs are a dynamic population of cells in varying stages of differentiation and activation, Lanny wants to determine if galectin-1 can have a different functional property depending on the DC stage of differentiation when galectin-1 is introduced.
One function of DCs is to activate naïve T cells, triggering them to proliferate and differentiate into a T cell subtype. The specific T cell subtype induced is determined by the stimulation conditions, namely interactions with co-stimulatory molecules expressed on and cytokines secreted by the DCs. Thus, Lanny will study the effects of galectin-1 on DC function by investigating the ability of these galectin-1 treated DCs to induce T cell polarization and activity.
Lanny would like to thank Dr. Lee for the opportunity to contribute to his lab. She is also extremely grateful for Sara and Maggie, the best mentors she could ever have hoped for, and would like to thank them for their patience, support, and guidance.
| Ms. Esperanza Arab
Ms. Esperanza Arab
Mentor: Dr. Gil Travish
Title: Preparation and Fabrication of Nano-Scale Metal and Dielectric Accelerating Structures
Esperanza is a third year Astrophysics Major and has been working on the Micro Accelerator Platform (MAP) for the Particle Beam Physics Lab since June 2008. While existing large particle accelerators are used for cancer radiation therapy and scientific research, the millimeter-scale Micro Accelerator Platform (MAP) will ultimately allow for revolutionary medical and industrial applications due to its manageable size and reproducibility. The MAP consists of an electron source and a sub-micron, all-dielectric particle accelerator. The dielectric structure is laser powered and has two slab-symmetric reflecting mirrors with a vacuum gap between them. A periodic coupling mechanism allows the laser to enter transversely through one mirror and is analogous to the slots of an optical diffraction grating. Esperanza has helped create a less intricate prototype test structure due to the demanding and extensive applications of nano-technology that are necessary to create the coupling mechanism in the dielectric structure. We have fabricated three metal test structures of varying substrates, thickness, and quality of gold and tested them using electron beam imaging. Fabrication of the final dielectric structure relies on methods and materials modeled after Vertical Cavity Surface-Emitting laser (VCSEL) construction and Distributed Bragg Reflector (DBR) layering techniques. An initial plan for producing an effective all-dielectric structure has been outlined from her research, and Esperanza is currently modifying HFSS simulations of the dielectric structure to bring in the sub-relativistic regime.
| Ms. Lindsay Williams
Ms. Lindsay Williams
Mentor: Dr. Sally Maliski
Title: The Meaning of Prostate Cancer Treatment Related Incontinence and Erectile Dysfunction in African-American Men
Lindsay is currently a third year student in the inaugural class of the undergraduate BSN program. She hails as the president of NSUCLA, the nursing student undergraduate organization. She also participates in the California Black Women's Health Project and the Council of Black Nurses. Within the school, she performs research on the differences in race in the coping process of prostate cancer survivors, and traveled to New Orleans in 2005 for Hurricane Katrina relief. Her motivation to continue in nursing is the dedication to whole patient, physically and mentally, and assisting underserved populations.
The purpose of the study is to describe the impact of prostate cancer treatment related incontinence and erectile dysfunction on African-American men, and test the hypothesis that a man’s image of masculinity changes because of the loss of sexual functioning. Analysis of transcripts revealed a transitional process, which all the men were found to go through. The first step is normalizing, commonly by using age as an excuse for sexual dysfunction. The next stage is balancing hopeful waiting with acceptance. The next progression is reexamining life priorities and social roles. The last stage is a change in what it means to be a man.